One of the most important shortcomings in multimorbid chronic diseases management and research is the lack of integration of social, societal and behavioral factors into the prediction of patient’s treatment responses and outcomes.

The aggregation of risk factors associated with unhealthy societal and environmental contexts represents a cluster of exposures that modify the course of disease trajectories in a specific way.

We aim at investigating a number of flagship scenarios that examine different facets of hypotheses on multimorbid chronic diseases trajectories.

We aim to translate knowledge gain in LIFE into improved routine care, clinical research and public policies for urban design and access to care.