LIFE (is MaDE of ChoiCes)

Optimizing health trajectories by leveraging social, urban and environmental data
Half of middle age adults exhibit more than two concomitant chronic diseases (“multimorbidity”). The progressive aggregation of chronic diseases across lifespan is drawing original health trajectories from multimorbidity to cancer. The overall goal of LIFE project is to examine the determinants of health trajectories by capturing underestimated yet crucial contributing factors including access to care, socio-economic factors, environmental exposures and urban design.
In this project, we are developing an integrated and multidisciplinary research plan uniting biological scientists, doctors, epidemiologists, public health specialists, social scientists, urban designers and big data researchers into a common framework for developing evidence-based societal and environmental control of health trajectories and transition to cancer.

Transdisciplinarity is the essence of LIFE (is MaDE of ChoiCes). The questions addressed by the program and the proposed solutions span a wide spectrum of expertise ranging from biology and medicine to social sciences, architecture and computer sciences. The conjecture underpinning the program is that its success requires the integration of six pillars (medicine, molecular markers, environmental exposures, socioeconomic disparities, city planning and computer sciences), providing stable and level ground for further transdisciplinary building.

LIFE will feed a unique scalable data processing pipeline and will allow developing a geocoded spatial mapping of transdisciplinary modulators of health trajectories. Knowledge generated by LIFE will facilitate action plans for improving healthcare organization and access, and for promoting healthy urban design and innovative medical interventions.

The proportion of the global population living in cities is predicted to rise to 60% by 2030, a 72% increase in 30 years. Understanding of how social and urban environment affect disease trajectories and can be leveraged to produce health benefits is therefore the cornerstone of the implementation of the Health21 agenda of WHO.

Awareness of environmental and urban impact on health is at the heart of numerous urban development plans, including Grenoble. With the urban and environmental challenges promoted by LIFE, its scientific radiance, and the international collaborations of the project stakeholders, the generated innovations will be a unique opportunity both locally and internationally.

Published on May 24, 2017