• Research

Identity crisis in pulmonary arterial hypertension. Pulm Circ. 2018 Jan-Mar;8(1):2045893217746054

Ruffenach G, Bonnet S, Rousseaux S, Khochbin S, Provencher S, Perros F
doi : 10.1177/2045893217746054
http://journals.sagepub.com/doi/abs/10.1177/2045893217746054


Abstract

Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes.


Published on August 23, 2018