• Research

Oncogenesis by Unprogrammed Gene Activation: A Critical Evaluation of Cancer Testis Genes - Reference Module in Biomedical Sciences, Elsevier, 2017

Sophie Rousseaux, Ekaterina Bourova-Flin, Mengqing Gao, Jin Wang, Jian-Qing Mi, Saadi Khochbin
doi: 10.1016/B978-0-12-801238-3.65107-3
https://www.sciencedirect.com/science/article/pii/B9780128012383651073

Abstract

Malignant cell reprogramming relies on systematic genetic and epigeneticupheavals generating cells that survive as cancer cells and eventually disseminate at distant places. Activation of hundreds of normally silent genes, including a category known as “cancer testis” (C/T) genes now clearly appears as a robust hallmark of oncogenic cell transformation. Although new data suggest that some of the previously established concepts about C/T genes need to be revised, C/T gene activation globally points to new applications ranging from diagnosis and prognosis tests to the development of new anti-cancer therapies.



Published on August 22, 2018