• Research

Oncogenesis by Unprogrammed Gene Activation: A Critical Evaluation of Cancer Testis Genes - Reference Module in Biomedical Sciences, Elsevier, 2017

Sophie Rousseaux, Ekaterina Bourova-Flin, Mengqing Gao, Jin Wang, Jian-Qing Mi, Saadi Khochbin
doi: 10.1016/B978-0-12-801238-3.65107-3


Malignant cell reprogramming relies on systematic genetic and epigeneticupheavals generating cells that survive as cancer cells and eventually disseminate at distant places. Activation of hundreds of normally silent genes, including a category known as “cancer testis” (C/T) genes now clearly appears as a robust hallmark of oncogenic cell transformation. Although new data suggest that some of the previously established concepts about C/T genes need to be revised, C/T gene activation globally points to new applications ranging from diagnosis and prognosis tests to the development of new anti-cancer therapies.

Published on August 22, 2018